Table 2.
Differentially Expressed Genes Regulated by SREBP Cleavage-Activating Protein in Neonatal Brains Exposed In Utero to BAC C12 or BAC C16
| BAC C12 |
BAC C16 |
||||
|---|---|---|---|---|---|
| Gene ID | Description | Log2(FC) | Adjusted p Value | Log2(FC) | Adjusted p Value |
| AACS | Acetoacetyl-CoA synthetase | 0.42 | 9.81E−03 | 0.35 | 3.84E–02 |
| ACSL4 | Acyl-CoA synthetase long-chain family member 4 | 0.51 | 4.44E–03 | ||
| ALB | Albumin | –2.19 | 4.44E–03 | –3.69 | 9.98E–03 |
| CYP51 | Cytochrome P450, family 51 | 0.58 | 3.23E–02 | ||
| DLK1 | Delta like non–canonical Notch ligand 1 | –0.53 | 2.70E–02 | ||
| ELOVL6 | ELOVL family member 6, elongation of long-chain fatty acids | 0.58 | 4.44E–03 | ||
| HMGCR | 3-hydroxy-3-methylglutaryl-CoenzymeA reductase | 0.57 | 4.44E–03 | ||
| HMGCS2 | 3-hydroxy-3-methylglutaryl-CoenzymeA synthase 2 | 0.69 | 4.44E–03 | 0.61 | 9.98E–03 |
| IDI1 | Isopentenyl-diphosphate delta isomerase | 0.91 | 4.44E–03 | ||
| INSIG1 | Insulin induced gene 1 | 0.41 | 9.81E–03 | ||
| LDLR | Low-density lipoprotein receptor | 0.87 | 4.44E–03 | 0.73 | 9.98E–03 |
| MSMO1 | Methylsterol monooxygenase 1 | 0.66 | 4.44E–03 | 0.48 | 9.98E–03 |
| MT2 | Metallothionein 2 | –0.48 | 1.66E–02 | ||
| MTHFD2 | Methylenetetrahydrofolate cyclohydrolase | –0.66 | 4.44E–03 | –0.53 | 9.98E–03 |
| PCSK9 | Proprotein convertase subtilisin/kexin type 9 | –0.81 | 4.44E–03 | ||
| SCD | Stearoyl-Coenzyme A desaturase | –0.36 | 1.98E–02 | ||
| SQLE | Squalene epoxidase | 0.62 | 4.44E–03 | 0.45 | 9.98E–03 |
n = 4 biological replicates per condition; adjusted p < .05.