Table 2.
Mean Onset and Duration of Action of the Initial Pantoprazole Dose (80 mg)
| Population | Onset of actiona (min) |
Duration of actionb (h) |
||
|---|---|---|---|---|
| Mean (SD) | Range | Mean (SD) | Range | |
| All patients by diagnosis (n = 21) | ||||
| Sporadic ZES (n = 14) | 43 (14) | 15–60 | 11.1 (2.6) | 2–12.0 |
| ZES + MEN-I (n = 7) | 39 (8) | 30–45 | 10.6 (2.8) | 4–12.0 |
| Total (n = 21) | 41 (12) | 15–60 | 10.9 (2.6) | 2–12.0 |
| All patients by regimen at efficacyc (n = 21) | ||||
| 80 mg every 12 h (n = 17) | 43 (12) | 30–60 | 12.0 (0) | 12.0–12.0 |
| 120 mg every 12 h (n = 2) | 30 (21) | 15–45 | 9.0 (0.4) | 8.75–9.25 |
| 80 mg every 8 h (n = 2) | 38 (±11) | 30–45 | 3.6 (1.6) | 2.5–4.75 |
| Total (n = 21) | 41 (12) | 15–60 | 10.9 (2.6) | 2.5–12.0 |
a
Onset is defined as the point at which acid output decreases to <10 mEq/h for patients who had not undergone prior acid-reducing surgery or to <5 mEq/h for patients who had undergone such surgery.
b
Duration of action is defined as the duration acid output remained under control after administration of IV pantoprazole with a maximal duration of 12 hours (the time at which a second IV dose was mandatory).
c
Efficacy is defined as control of acid output for any 24-hour period over the course of active therapy, at <10 mEq/h for patients who had not undergone prior acid-reducing surgery or <5 mEq/h for patients who had undergone such surgery.