Figure 4.

Gene expression of human cardiomyocytes treated for 6 h with 100 ng/ml Midkine. mRNA expression (in fold change) of sarco/endoplasmatic reticulum Ca²⁺-ATPase (SERCA2a) (A), ryanodine receptor-1 (RyR1) (B), sodium-calcium exchanger (NCX) (C), purigenic P2X receptor subtype 7 (P2X7) (D), toll-like receptor 4 (TLR4) (E), toll-like receptor 9 (TLR9) (F). Results are presented as mean ± SEM. Data were analyzed by two-tailed, unpaired students t-test. For all experiments n = 6. Results are significant *p < 0.05.