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. 2019 Aug 21;10:1920. doi: 10.3389/fimmu.2019.01920

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Copyright © 2019 Lackner, Weber, Baur, Haffner-Luntzer, Eiseler, Fois, Gebhard, Relja, Marzi, Pfeifer, Halvachizadeh, Lipiski, Cesarovic, Pape, Kalbitz and TREAT Research Group.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Filtration of Midkine by CytoSorb® 300. Filtration of different Midkine concentrations (10,000, 5,000, 2,500, 2,000, 1,500, 1,000 pg/ml) (n = 6) with CytoSorb® 300 after 3 h (black bars) and 6 h (white bars) (A). Midkine concentration before and after filtration with CytoSorb® 300 on the x-axis in pg/ml. Midkine levels (pg/ml) in human shock room blood plasma of multiply injured patients before and after filtration with CytoSorb® 300 (n = 11) (B). Results are presented as mean ± SEM. Data were analyzed by one-way ANOVA followed by Dunnett's or Tukey's multiple comparison test. Results are significant *p < 0.05.