Fig. 4.
Electrophysiological effects of CNO on VH pyramidal cells. A. Confocal image of a patched VH cell injected with biocytin corroborating the morphological properties of pyramidal cells. B. Recordings from a D READD + cell. Before CNO application a small current step (100pA) does not elicit action potentials; however, the same current elicits robust firing after drug is applied to the bath. C. Recordings from a DREADD- cell. Before and after CNO application the cell does not respond to a small current (100 pA).