Table 1.
Incidence rates of diabetes, acute myocardial infarction (AMI), and stroke among a cohort of patients formerly treated for tuberculosis, Taiwan National Health Insurance Research Database (NHIRD), 2002–2013.
| Characteristics | Diabetes | AMI | Stroke | |||
|---|---|---|---|---|---|---|
| N (%) = 2479 (1.97%) | N (%) = 2287 (1.59%) | N (%) = 9539 (8.08%) | ||||
| Total PTY = 643754 | Total PTY = 700890 | Total PTY = 596395 | ||||
| Overall IR = 3.85 (3.70–4.01) | Overall IR = 3.26 (3.13–3.40) | Overall IR=15.99 (15.68–16.32) | ||||
| N/PTY | IR (95% CI) | N/PTY | IR (95% CI) | N/PTY | IR (95% CI) | |
| Age group | ||||||
| 15–24 | 14/55138 | 0.25 (0.15–0.43) | Excluded | N/A | Excluded | N/A |
| 25–44 | 344/151792 | 2.27 (2.04–2.52) | 68/162616 | 0.42 (0.33–0.53) | 530/159684 | 3.32 (3.05–3.61) |
| 45–64 | 959/179001 | 5.36 (5.03–5.71) | 663/229965 | 2.88 (2.67–3.11) | 2788/211591 | 13.18 (12.70–13.67) |
| ≥65 | 1162/257823 | 4.51 (4.26–4.77) | 1556/308309 | 5.05 (4.80–5.30) | 6275/225120 | 27.87 (27.19–28.57) |
| Gender | ||||||
| Female | 639/217826 | 2.93 (2.72–3.17) | 490/223450 | 2.19 (2.01–2.40) | 2447/194418 | 12.59 (12.10–13.09) |
| Male | 1840/422458 | 4.36 (4.16–4.56) | 1797/474570 | 3.79 (3.62–3.97) | 7146/399157 | 17.90 (17.49–18.32) |
| Unknown | 0/3470 | N/A | 0/2870 | N/A | 0/2820 | N/A |
| TB site | ||||||
| Pulmonary | 2145/547526 | 3.92 (3.76–4.09) | 2001/600655 | 3.33 (3.19–3.48) | 8331/512211 | 16.26 (15.92–16.62) |
| Extrapulmonary | 320/91256 | 3.51 (3.14–3.91) | 264/94947 | 2.78 (2.47–3.14) | 1206/79812 | 15.11 (14.28–15.99) |
| Miliary | 14/4972 | 2.82 (1.67–4.75) | 22/5288 | 2.74 (2.74–6.32) | 56/4372 | 12.81 (9.86–16.64) |
| TB treatment duration | ||||||
| ≤6 months | 1749/469072 | 3.73 (3.56–3.91) | 1564/504205 | 3.10 (2.95–3.26) | 6698/428522 | 15.63 (15.26–16.01) |
| 7–12 months | 668/159157 | 4.20 (3.89–4.53) | 656/178856 | 3.67 (3.40–3.96) | 2633/152429 | 17.27 (16.63–17.95) |
| >12 months | 62/15525 | 3.99 (3.11–5.12) | 67/17829 | 3.76 (2.96–4.78) | 262/15444 | 16.96 (15.03–19.15) |
| Dyslipidemiaa | ||||||
| No | 2108/574547 | 3.67 (3.52–3.83) | 1766/599014 | 2.95 (2.81–3.09) | 7900/518986 | 15.22 (14.89–15.56) |
| Yes | 371/69207 | 5.36 (4.84–5.94) | 521/101876 | 5.11 (4.69–5.57) | 1693/77409 | 21.87 (20.85–22.94) |
| Hypertensiona | ||||||
| No | 1410/448700 | 3.14 (2.98–3.31) | 917/444348 | 2.06 (1.93–2.20) | 4795/415207 | 11.55 (11.23–11.88) |
| Yes | 1069/195054 | 5.48 (5.16–5.82) | 1370/256542 | 5.34 (5.07–5.63) | 4798/181188 | 26.48 (25.74–27.24) |
| Overweighta | ||||||
| No | 2456/641308 | 3.83 (3.68–3.98) | 2276/697646 | 3.26 (3.13–3.40) | 9554/593576 | 16.10 (15.78–16.42) |
| Yes | 23/2446 | 9.40 (6.25–14.15) | 11/3244 | 3.39 (1.88–6.12) | 39/2819 | 13.83 (10.11–18.94) |
| HIVa | ||||||
| No | 2474/639526 | 3.87 (3.72–4.02) | 2276/696710 | 3.27 (3.14–3.41) | 9579/592428 | 16.17 (15.85–16.50) |
| Yes | 5/4228 | 1.18 (0.49–2.84) | 8/4180 | 1.91 (0.96–3.83) | 14/3967 | 3.53 (2.09–5.96) |
| CKDa | ||||||
| No | 2378/612063 | 3.89 (3.73–4.05) | 1985/660103 | 3.01 (2.88–3.14) | 8870/567777 | 15.62 (15.30–15.95) |
| Yes | 101/31691 | 3.19 (2.62–3.87) | 302/40787 | 7.40 (6.62–8.29) | 723/28618 | 25.26 (23.49–27.17) |
| Diabetesa | Excluded | |||||
| No | 1512/582699 | 2.60 (2.47–2.73) | 7183/502688 | 14.29 (13.96–14.62) | ||
| Yes | 775/118191 | 6.56 (6.11–7.04) | 2410/93707 | 25.72 (24.71–26.77) | ||
| Myocardial infarctiona | Excluded | |||||
| No | 2457/637226 | 3.86 (3.71–4.01) | 9453/590847 | 16.00 (15.68–16.32) | ||
| Yes | 22/6528 | 3.37 (2.22–5.12) | 140/5548 | 25.23 (21.38–29.78) | ||
| Strokea | ||||||
| No | 2133/563277 | 3.79 (3.63–3.95) | 1707/598831 | 2.85 (2.72–2.99) | Excluded | |
| Yes | 346/80477 | 4.30 (3.87–4.78) | 580/102059 | 5.68 (5.24–6.17) | ||
Notes:
Abbreviation: AMI - Acute Myocardial Infarction; IR - incidence rate; CI - Confidence Interval; PTY - person time in years.
a
Comorbidities (i.e., dyslipidemia, hypertension, overweight, HIV, and chronic kidney disease) were diagnosed earlier or at the time of TB diagnosis.