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. Author manuscript; available in PMC: 2020 Sep 15.
Published in final edited form as: Bioorg Med Chem Lett. 2019 Jul 10;29(18):2695–2699. doi: 10.1016/j.bmcl.2019.07.012

Table 4.

Matched pair comparison of benzyloxyaniline.

graphic file with name nihms-1537187-t0007.jpg
Compound R1 R2 R3 R4 Mtb signala (μM) WS-1b
1.25 2.5 5 10 20 (μM)
29 OMe OMe OH A 1.14 1.09 1.13 1.05 0.45 16
30 OMe OMe OH B 1.10 1.12 1.06 0.72 0.25 2.6
31 OMe OMe H C 1.21 1.10 1.11 1.07 1.02 9.7
32 OMe H OH A 1.11 1.17 1.14 1.28 0.95 10
33 H OMe OH A 1.13 1.11 1.09 1.11 0.96 4.7
34 OMe OMe H D 0.43 0.17 0.10 0.08 0.09 5.4
a

Relative luminescence was measured at 3 days after treatment. Values = RLU(sample)/RLU(no compound);

b

IC50 (mean average n=4), 48 h