A2.

Cheson Response Criteria (CT/MRI)

Response category	Physical examination	Lymph nodes	Lymph nodes masses	Bone marrow
CT, computed tomography; MRI, nuclear magnetic resonance; CR, complete response; CRu, uncomfirmed complete response; PR, partial response.
CR	Normal	Normal	Normal	Normal
CRu	Normal	Normal	Normal	Indeterminate
	Normal	Normal	>75% decrease	Normal or indeterminate
PR	Normal	Normal	Normal	Positive
	Normal	≥50% decrease	≥50% decrease	Irrelevant
	Decrease in liver/spleen	≥50% decrease	≥50% decrease	Irrelevant
Relapse/progression	Enlarging liver/spleen; new sites	New or increased	New or increased	Reappearance