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FAT1 exhibits genetic alterations with high frequency in esophageal squamous cell carcinoma (ESCC). (A) Frequency of FAT1 mutations in ESCC. Green box, cadherin domain; Red box, laminin G-like domain; Blue box, epidermal growth factor (EGF)-like domain; Yellow box, calcium-binding EGF domain; Black ball, truncating mutation; Green ball, missense mutation; Brown ball, inframe mutation; Pink ball, other mutation; (B) Frequency of FAT1 copy number variants (CNVs) in three types of squamous cell carcinomas and tumor cell lines. The percentage represents the approximate ratio of CNVs. Red box, amplification; Blue box, deletion. LUSCC, lung squamous cell carcinoma; HNSCC, head and neck squamous cell carcinoma; TC, tumor cell lines.