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. 2019 Aug;31(4):578–585. doi: 10.21147/j.issn.1000-9604.2019.04.02

A3.

M stage

M stage Staging criteria
Anatomic site LDH level
AJCC, American Joint Committee on Cancer; SLN, sentinel lymph node; CNS, central nervous system; LDH, lactate dehydrogenase.
M0 No evidence of distant metastasis Not applicable
M1 Evidence of distant metastasis See below
 M1a Distant metastasis to skin, soft tissue including muscle, and/or nonregional lymph node Not recorded or unspecified
  M1a (0) Not elevated
  M1a (1) Elevated
 M1b Distant metastasis to lung with or without M1a sites of disease Not recorded or unspecified
  M1b (0) Not elevated
  M1b (1) Elevated
 M1c Distant metastasis to non-CNS visceral sites with or without M1a or M1b sites of disease Not recorded or unspecified
  M1c (0) Not elevated
  M1(1) Elevated
 M1d Distant metastasis to CNS with or without M1a, M1b, or M1c sites of disease Not recorded or unspecified
  M1d (0) Not elevated
  M1d (1) Elevated