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. Author manuscript; available in PMC: 2020 Sep 15.
Published in final edited form as: J Immunol. 2019 Aug 7;203(6):1650–1664. doi: 10.4049/jimmunol.1801236

Figure 7. H and L chain V family and gene usage of DN and IgD−CD27+ memory B cells of HC and MS patients.

Figure 7.

IGHV (A), IGKV and IGLV (B) family usage is depicted for the DN and IgD−CD27+ memory B cell compartments. (C) V gene segment usage is shown for DN and IgD−CD27+ memory B cells. Usage is shown as a percent of the total unique IGHV, IGKV or IGLV sequences (y-axis) for HC and MS patients. Horizontal bars indicate the mean abundance over all subjects of a given status and compartment, while vertical shading indicates ± 1 SD about the mean. As a reference, gene usage in naïve B cells from HC is indicated by the dashed lines (mean) and horizontal gray shaded areas (± 1 SD). Families IGHV6 and IGHV7 are not shown. * FDR < 0.20 and p < 0.05