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. Author manuscript; available in PMC: 2019 Oct 1.
Published in final edited form as: J Steroid Biochem Mol Biol. 2019 Jun 29;193:105422. doi: 10.1016/j.jsbmb.2019.105422

Fig. 1. The human adrenal cortex remodels to generate clusters of cells expressing DLK1.

Fig. 1.

A-E) Expression of DLK1 mRNA in human fetal adrenals showing a subcapsular layered-continuous pattern in the definitive zone (DZ). F-G) DLK1 protein expression in a 0.6 yo and 20 yo adrenal showing a subcapsular layered-continuous pattern. H) A round-shaped subcapsular DCC in a 35 yo adrenal. I) A columnar-shaped DCC in a 47 yo adrenal. J) Expression of DLK1 mRNA in a 50 yo adrenal showing multiple DCCs and absence of a layered-continuous pattern of DLK1 expression. K) Control sense probe in an adjacent section to J. L) From the third decade onwards, large areas of the cortex were devoid of either clustered or layered-continuous DLK1 staining, and have single cells sparingly expressing DLK1 or no DLK1 expression at all. Abbreviations: Cap, capsule; DCC, DLK1 cells cluster; DZ, Definitive Zone; FZ, fetal Zone; ZG, Zona Glomerulosa; ZF, Zona Fasciculata. Scale bars A, B = 75 μm; C = 200 μm; D, E, G, H, I, L = 100 μm; F = 500 μm; J = 1500 μm.

Hadjidemetriou et al., Fig 2 (1.5 columns fitting).