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. Author manuscript; available in PMC: 2020 Oct 15.
Published in final edited form as: Stat Med. 2019 Jul 17;38(23):4503–4518. doi: 10.1002/sim.8310

Figure 2:

Figure 2:

(A) Observed VRC01 concentrations W at 0, 3 days and 2, 4, 8 weeks after each of the three infusions, and at one hour and 10–16 weeks after the last infusion for the 10 mg/Kg (left) and 30 mg/Kg (right) VRC01 dose arms in HVTN 104. (B) Predicted and observed dose-normalized VRC01 concentrations in HVTN 104 after a single (left) and multiple (right) intravenous infusion(s) based on the final popPK model described in Huang et al.10 (C) Simulated time-concentration data under perfect study adherence. Solid lines are medians; shaded areas are 2.5th and 97.5th percentiles over 500 simulated data sets. A body weight of 74.5 Kg is used.