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. Author manuscript; available in PMC: 2020 Oct 15.
Published in final edited form as: Stat Med. 2019 Jul 17;38(23):4503–4518. doi: 10.1002/sim.8310

Figure 3:

Figure 3:

Power to detect VRC01 concentration over time as a correlate of HIV infection for the perfect study adherence scenarios with case:control ratios 1:1, 1:2, 1:4. The effect sizes parametrized by β0 are shown as 28-day hazard ratios (exp(28*β0)). Solid lines are based on true (estimated) infection event times. Mean PE-10 (Mean PE-30) is average empirical prevention efficacy over the 500 simulated trials for the 10 (30) mg/Kg VRC01 dose group. Mean No. Cases is the total number of VRC01 recipient cases averaged over the 500 simulated trials.