Table 1:

Application of the Times Method, Marker Method, Lin (2000) Cox model, and Case-Only Sign Test to the Pseudo-AMP Trial Data Set^a.

Approach (95% CI)	No. Cases in Analysis (n = 64)	Target Parameter	Estimate of the Parameter (95% CI)	Two-sided P-value
Times	58 (91%)	$\frac{1}{2}{\widehat{\mu }}^{Tctrl}$	27.98 (27.96, 28.01)
Method		${\widehat{\mu }}^{Tcase}$	32.17 (28.69, 35.65)
		${\widehat{\mu }}^T$	4.19 (0.70, 7.67)	0.018
Repeat	30 (47%)	$\frac{1}{2}{\widehat{\mu }}^{Tctrl}$	32.27 (32.24, 32.30)
Excluding		${\widehat{\mu }}^{Tcase}$	39.83 (35.29, 44.37)
+++ FP		${\widehat{\mu }}^T$	7.56 (3.03, 12.10)	0.001
Marker	60 (94%)	${\widehat{\mu }}^{Sctrl}$	3.40 (3.33, 3.47)
Method		${\widehat{\mu }}^{Scase}$	3.17 (2.96, 3.39)
		${\widehat{\mu }}^S$	0.23 (0.003, 0.45)	0.047
Repeat	31 (48%)	${\widehat{\mu }}^{Sctrl}$	3.16 (3.10, 3.23)
Excluding		${\widehat{\mu }}^{Scase}$	2.73 (2.45, 3.02)
+++ FP		${\widehat{\mu }}^S$	0.43 (0.14, 0.72)	0.004
Cox Model	60 (94%)	Hazard Ratio	0.82 (0.66, 1.02)	0.071
		Per Incr. Conc.
Repeat	31 (48%)	Hazard Ratio	0.61 (0.48, 0.77)	0.002
Excluding		Per Incr. Conc.
+++ FP
Case-Only	55 (86%)	Prob. Infected	0.64 (0.496, 0.76)	0.058
Sign Test		Second-Half
Repeat	29 (45%)	Prob. Infected	0.69 (0.49, 0.85)	0.061
Excluding		Second-Half
+++ FP

^aThe four methods are implemented as described for the simulation study. Target parameters for controls are modified for the Times and Marker methods, and the null value for the Cox model was modified as described in Section 5.4.