Table 1.
Characteristics of patients with desmoid-type fibromatosis managed with either immediate intervention or an initial trial of active observation.
| Total (n=160) | Active observation (n=72) | Immediate intervention (n=88) | p-value | |
|---|---|---|---|---|
| Gender | 0.38* | |||
| Male | 52 (32%) | 22 (31%) | 30 (34%) | |
| Female | 108 (68%) | 50 (69%) | 58 (66%) | |
| Age, yrs | 0.08 | |||
| ≤25 | 23 (14%) | 13 (18%) | 10 (11%) | |
| ˃25, ≤45 | 73 (46%) | 33 (46%) | 40 (45%) | |
| ˃45, ≤65 | 50 (31%) | 24 (33%) | 26 (29%) | |
| >65 | 14 (8.8%) | 2 (2.7%) | 12 (14%) | |
| Location of primary tumor | 0.02 | |||
| Abdominal wall | 31 (19%) | 19 (26%) | 12 (14%) | |
| Chest wall | 25 (16%) | 5 (6.9%) | 20 (23%) | |
| GI/intra-abdominal | 53 (33%) | 21 (29%) | 32 (36%) | |
| Extremity | 42 (26%) | 21 (29%) | 21 (24%) | |
| Other | 9 (5.6%) | 6 (8.3%) | 3 (3.4%) | |
| Size of treated tumor | 0.08 | |||
| ≤5 cm | 48 (30%) | 28 (39%) | 20 (23%) | |
| 5–10 cm | 79 (49%) | 32 (44%) | 47 (53%) | |
| ≥10 cm | 33 (21%) | 12 (17%) | 21 (24%) | |
| Presentation status | 0.16 | |||
| Primary | 118 (74%) | 50 (69%) | 68 (77%) | |
| Local recurrence | 37 (23%) | 21 (29%) | 16 (18%) | |
| Residual disease | 5 (3.1%) | 1 (1.4%) | 4 (4.5%) | |
| Symptoms | 0.04* | |||
| Yes | 72 (45%) | 33 (46%) | 55 (63%) | |
| No | 88 (55%) | 39 (54%) | 33 (38%) | |
| Date of presentation | 0.36* | |||
| 2008 – 2010 | 77 (48%) | 33 (46%) | 44 (50%) | |
| 2011 – 2015 | 83 (52%) | 39 (54%) | 44 (50%) | |
| Initial therapy | ||||
| Surgical resection | n/a | n/a | 61 (76%) | n/a |
| Radiation | 1 (1.1%) | |||
| Systemic therapy | 25 (28%) | |||
| Cryoablation | 1 (1.1%) |
*
Calculated using Fisher’s exact test, all other values represent results of χ2 analysis.