Table S2. Univariate and multivariate Cox regression analyses of thoracic ESCC patients and the relationship between tumor location and Chinese Criteria grouping.
| Character | All patients | Upper mediastinum | Lower mediastinum | ||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Univariate analyses | Multivariate analyses | Univariate analyses | Multivariate analyses | Univariate analyses | Multivariate analyses | ||||||||||||
| P | HR, 95% CI | P | HR, 95% CI | P | HR, 95% CI | P | HR, 95% CI | P | HR, 95% CI | P | HR, 95% CI | ||||||
| Gender | 0.002 | 0.785 (0.672–0.917) | 0.303 | 0.918 (0.785–1.075) | 0.510 | 0.890 (0.630–1.258) | – | – | 0.002 | 0.757 (0.636–0.901) | 0.145 | 0.879 (0.737–1.049) | |||||
| Male | Ref | Ref | Ref | Ref | Ref | Ref | – | – | Ref | Ref | Ref | Ref | |||||
| Female | 0.002 | 0.785 (0.672–0.917) | 0.303 | 0.918 (0.785–1.075) | 0.510 | 0.890 (0.630–1.258) | – | – | 0.002 | 0.757 (0.636–0.901) | 0.145 | 0.879 (0.737–1.049) | |||||
| Differentiation | <0.001 | 1.214 (1.104–1.334) | 0.112 | 1.099 (0.898–1.211) | 0.183 | 1.203 (0.963–1.502) | – | – | 0.001 | 1.225 (1.103–1.360) | 0.084 | 1.263 (0.811–1.610) | |||||
| High | Ref | Ref | Ref | Ref | Ref | Ref | – | – | Ref | Ref | Ref | Ref | |||||
| Moderate | 0.111 | 1.192 (0.960–1.478) | 0.869 | 1.018 (0.820–1.266) | 0.225 | 1.028 (0.663–1.595) | – | – | 0.069 | 1.260 (0.982–1.617) | 0.113 | 1.062 (0.826–1.366) | |||||
| Low | 0.001 | 1.458 (1.171–1.814) | 0.196 | 1.159 (0.927–1.448) | 0.066 | 1.359 (0.862–2.142) | – | – | 0.001 | 1.526 (1.186–1.964) | 0.029 | 1.211 (1.045–1.580) | |||||
| Adjuvant therapy | 0.494 | 1.044 (0.923–1.182) | – | – | 0.856 | 0.972 (0.714–1.323) | – | – | 0.413 | 1.058 (0.924–1.211) | – | – | |||||
| No | Ref | Ref | – | – | Ref | Ref | – | – | Ref | Ref | – | – | |||||
| Yes | 0.494 | 1.044 (0.923–1.182) | – | – | 0.856 | 0.972 (0.714–1.323) | – | – | 0.413 | 1.058 (0.924–1.211) | – | – | |||||
| T stage | <0.001 | 1.620 (1.484–1.769) | <0.001 | 1.407 (1.284–1.540) | <0.001 | 1.560 (1.273–1.912) | <0.001 | 1.526 (1.235–1.886) | <0.001 | 1.638 (1.485–1.805) | <0.001 | 1.400 (1.266–1.548) | |||||
| T1 | Ref | Ref | Ref | Ref | Ref | Ref | Ref | Ref | Ref | Ref | Ref | Ref | |||||
| T2 | <0.001 | 1.580 (1.162–2.147) | 0.084 | 1.313 (0.965–1.788) | 0.224 | 1.492 (0.783–2.846) | 0.886 | 1.050 (0.543–2.027) | 0.006 | 1.631 1.150–2.313) | 0.059 | 1.402 (0.987–1.992) | |||||
| T3 | <0.001 | 2.721 (2.078–3.562) | <0.001 | 1.989 (1.513–2.616) | 0.006 | 2.195 (1.260–3.826) | 0.039 | 1.808 (1.030–3.176) | <0.001 | 2.905 (2.133–3.956) | <0.001 | 2.106 (1.539–2.883) | |||||
| T4 | <0.001 | 4.065 (2.970–5.562) | <0.001 | 2.610 (1.894–3.579) | <0.001 | 3.980 (2.043–7.755) | 0.001 | 3.154 (1.595–6.239) | <0.001 | 4.172 (2.920–5.961) | <0.001 | 2.635 (1.830–3.794) | |||||
| N stage | <0.001 | 1.755 (1.651–1.864) | <0.001 | 1.442 (1.279–1.626) | <0.001 | 1.755 (1.495–2.060) | <0.001 | 1.685 (1.434–1.980) | <0.001 | 1.759 (1.647–1.878) | <0.001 | 1.654 (1.543–1.772) | |||||
| N0 | Ref | Ref | Ref | Ref | Ref | Ref | Ref | Ref | Ref | Ref | Ref | Ref | |||||
| N1 | <0.001 | 2.001 (1.727–2.319) | <0.001 | 1.849 (1.593–2.146) | <0.001 | 2.180 (1.545–3.076) | <0.001 | 2.140 (1.511–3.031) | <0.001 | 1.961 (1.666–2.307) | <0.001 | 1.781 (1.510–2.101) | |||||
| N2 | <0.001 | 3.264 (2.791–3.818) | <0.001 | 2.935 (2.500–3.445) | <0.001 | 2.812 (1.862–4.271) | <0.001 | 2.750 (1.806–4.188) | <0.001 | 3.354 (2.830–3.976) | <0.001 | 2.969 (2.494–3.535) | |||||
| N3 | <0.001 | 5.073 (4.032–6.383) | <0.001 | 4.518 (3.579–5.702) | <0.001 | 6.165 (3.289–11.544) | <0.001 | 4.986 (2.606–9.358) | <0.001 | 4.983 (3.891–6.380) | <0.001 | 4.417 (3.439–5.674) | |||||
| Tumor location | 0.171 | 0.894 (0.761–1.050) | – | – | – | – | – | – | – | – | – | – | |||||
| Upper mediastinum | Ref | Ref | – | – | – | – | – | – | – | – | – | – | |||||
| Lower mediastinum | 0.171 | 0.894 (0.761–1.050) | – | – | – | – | – | – | – | – | – | – | |||||
| Age (y) | 0.011 | 1.188 (0.761–1.050) | 0.001 | 1.261 (1.103–1.441) | 0.344 | 1.186 (0.833–1.686) | – | – | 0.016 | 1.194 (1.034–1.379) | 0.003 | 1.242 (1.075–1.434) | |||||
| <55 | Ref | Ref | Ref | Ref | Ref | Ref | – | – | Ref | Ref | Ref | Ref | |||||
| ≥55 | 0.011 | 1.188 (0.761–1.050) | 0.001 | 1.261 (1.103–1.441) | 0.344 | 1.186 (0.833–1.686) | – | – | 0.016 | 1.194 (1.034–1.379) | 0.003 | 1.242 (1.075–1.434) | |||||
| Chinese Criteria grouping | <0.001 | 1.370 (1.319–1.423) | <0.001 | 1.261 (1.103–1.441) | <0.001 | 1.381 (1.257–1.518) | <0.001 | 1.391 (1.264–1.530) | <0.001 | 1.371 (1.315–1.429) | <0.001 | 1.312 (1.257–1.370) | |||||
| No | Ref | Ref | Ref | Ref | Ref | Ref | Ref | Ref | Ref | Ref | Ref | Ref | |||||
| Skip | <0.001 | 1.892 (1.494–2.397) | <0.001 | 1.614 (1.285–2.310) | 0.007 | 1.806 (1.178–2.768) | 0.018 | 1.690 (1.096–2.607) | 0.003 | 1.603 (1.176–2.184) | 0.010 | 1.503 (1.101–2.050) | |||||
| Local | <0.001 | 2.320 (2.012–2.676) | <0.001 | 2.123 (1.837–2.454) | <0.001 | 2.234 (1.498–3.329) | <0.001 | 2.300 (1.537–3.441) | <0.001 | 2.403 (2.063–2.801) | <0.001 | 2.179 (1.865–2.545) | |||||
| Mediastinal | <0.001 | 3.857 (3.271–4.547) | <0.001 | 3.367 (2.843–3.987) | <0.001 | 4.436 (2.987–6.588) | <0.001 | 4.341 (2.894–6.514) | <0.001 | 3.756 (3.134–4.503) | <0.001 | 3.225 (2.675–3.888) | |||||
ESCC, esophageal squamous cell carcinoma; no, no metastasis group; skip, skip metastasis group; local, local metastasis group; mediastinal, mediastinal metastasis group; HR, hazard ratio; 95% CI, 95% confidence interval; Ref, reference.