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. 2019 Aug;7(16):394. doi: 10.21037/atm.2019.07.51

Table 2. Overview of reported serological markers for human mesenteric ischemia.

Biomarkers Release site or active site Sensitivity (95% CI) Specificity (95% CI) Limitations Diagnostic values
I-FABP
   Serum Mature enterocyte 80% (72–86%) 85% (73–93%) (39) No significant difference in I-FABP concentrations for mucosal and transmural ischemia Early stage
   Urine 90% 89% (40)
a-GST Mature enterocyte 68% (55–80%) 85% (76–92%) (22,41) a-GST also increases in non-specific hypotensive patients with multiple organ failures Early stage
D-dimer Blood 96% 40% (22) lower specificity
L -lactate 96% 40% (22) Low specificity Late stage
D-lactate Bacterial fermentation in gastrointestinal tract 71.7% (58.6–82.5%) 74.2% (69.0–79.0%) (42) low specificity Late stage
82% 36% (43)
Citrulline Mature small bowel enterocyte 39% 100% (42) Low Sensitivity
IMA 94.7% (74.0–99.9%) 86.4% (65.1–97.1%) (42) myocardial ischemia may induce the elevation of plasma IMA levels
PCT Liver parenchyma in pathologic conditions 72–100% 68–91% (44) bacterial infection, sepsis and various types of ischemias may also increase PCT levels Depend on the threshold values
SM-22 Smooth muscle fail to accurately diagnose AMI at an early ‘‘nontransmural’’ stage Late stage