Table 1. Characteristics of patients and factors correlated with prognosis.

Variables	Patient characteristics	n [%]	Univariate analysis				Multivariate analysis
			HR	95% CI	P value		HR	95% CI	P value
Age	≤60	45 [63]	1.000	–	–
	>60	27 [37]	0.558	0.265–1.171	0.123
Gender	Male	41 [57]	1.000	–	–
	Female	31 [43]	0.568	0.276–1.168	0.124
Status at admission	Recurrence	59 [82]	1.000	–	–
	New diagnosis	13 [18]	0.719	0.278–1.859	0.496
Histology	UPS	21 [29]	1.000	–	–
	MFS	18 [25]	0.648	0.264–1.590	0.343
	FS	8 [11]	0.535	0.151–1.898	0.333
	LPS	6 [8]	1.061	0.341–3.303	0.918
	LMS	4 [6]	0.504	0.112–2.272	0.373
	SS	4 [6]	0.492	0.064–3.798	0.497
	Other STS	11 [15]	0.496	0.160–1.541	0.226
Localization	Lower extremity	29 [40]	1.000	–	–
	Upper extremity	10 [14]	1.284	0.445–3.705	0.643
	Trunk	24 [33]	1.312	0.568–3.028	0.525
	Hip	5 [7]	3.132	0.992–9.892	0.052
	Other	4 [6]	2.633	0.726–9.544	0.141
Grading (WHO)	G1 + G2	15 [21]	1.000	–	–
	G3	57 [79]	2.625	0.922–7.470	0.071
T stage	pT1a + pT1b	31 [43]	1.000	–	–
	pT2a + pT2b	41 [57]	2.741	1.302–5.771	0.008
TNM stage	I + II	34 [47]	1.000	–	–		1.000	–	–
	III + IV	38 [53]	2.605	1.264–5.369	0.009		2.795	1.354–5.773	0.005
Surgical margins	Wide	55 [76]	1.000	–	–
	Non-wide	17 [24]	1.379	0.643–2.959	0.409
Treatment between the 1st and 2nd surgery	None	55 [76]	1.000	–	–
	Chemo or (and) radio	17 [24]	0.943	0.427–2.083	0.884
CD8	Increase group	20 [28]	1.000	–	–		1.000	–	–
	No change group	26 [36]	1.604	0.593–4.338	0.352		1.662	0.614–4.499	0.317
	Decrease group	26 [36]	2.937	1.150–7.499	0.024		3.226	1.261–8.254	0.015
PD-L1(T)	Increase group	26 [36]	1.000	–	–
	No change group	38 [53]	0.969	0.477–1.970	0.932
	Decrease group	8 [11]	0.340	0.076–1.519	0.158
PD-L1(L)	Increase group	24 [33]	1.000	–	–
	No change group	40 [56]	1.075	0.515–2.246	0.847
	Decrease group	8 [11]	0.391	0.086–1.779	0.225
CD20	Increase group	17 [24]	1.000	–	–
	No change group	35 [49]	1.289	0.538–3.091	0.569
	Decrease group	20 [27]	1.223	0.455–3.288	0.689
Foxp3	Increase group	16 [22]	1.000	–	–
	No change group	32 [45]	1.243	0.511–3.023	0.631
	Decrease group	24 [33]	1.053	0.408–2.719	0.914

Surgical margins for the 1st surgery resection. PD-L1, programmed cell death ligand 1; PD-L1(T), PD-L1 in tumor cells; PD-L1(L), PD-L1 in lymphocytes; UPS, undifferentiated pleomorphic sarcoma; MFS, myxofibrosarcoma, FS, fibrosarcoma; LPS, liposarcoma; LMS, leiomyosarcoma; SS, synovial sarcoma; AS, angiosarcoma; STS, soft tissue sarcomas.