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. 2019 Sep 10;9:13020. doi: 10.1038/s41598-019-49448-8

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Change in tumor-to-background contrast for each processing technique: Conventional (Conv.), adaptive demodulation (AD) + Conv., mean phase shift (MPS) + Conv., IIR, AD + IIR, SVD, AD + SVD. The median value for each method is the central mark in each box. The 25th and 75th percentiles are the bottom and top edges of each box, respectively. The bars extending from each box indicate the minimums and maximums, and outliers are marked in red. Statistically significant differences from the conventional method are indicated with *(p < 0.05) and **(p < 0.01).