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. 2019 Sep 10;9:13020. doi: 10.1038/s41598-019-49448-8

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Average contrast (left) and change in contrast (right) for varying ensemble sizes and for each processing method: IIR (orange), adaptive demodulation (AD) + IIR (purple), SVD (black), and AD + SVD (green). On the left, contrast values before and after TACE are shown as the solid and dashed curves, respectively. On the right, change in contrast for when no tissue filtering is used is shown in teal for reference. The no tissue filter values are negative likely because the lipiodol used during TACE is hyperechoic and becomes structure in the tumor.