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. 2019 Sep 10;9:12973. doi: 10.1038/s41598-019-49480-8

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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The combination of CPT and silencing PDK1 significantly inhibited liver metastasis of CRC by down-regulating p-STAT3-Y705 in the immune competent mice model. (A) 5 × 10⁶ HCT116 cells with or without PDK1 shRNA transduction were injected into the spleens of BALB/C mice under isoflurane anesthesia, respectively. CPT (0.2 mg/d/mouse) were injected (i.p.) every other day (day 1, 3, 5, 7) for a total of four times. On day 9, the mice were sacrificed, and the liver metastatic area was measured by ImageJ software. The combination of CPT and PDK1 shRNA treatment led to a smallest liver metastasis area, compared with the control or PDK1 shRNA treatment alone. (B) Histogram indicated the corresponding comparison of liver metastasis areas presented in (A). Data expressed as mean ± S.D., **** represents P < 0.0001.