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. 2019 Sep 10;9:12938. doi: 10.1038/s41598-019-49350-3

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Spatio-temporal growth model for myelin-like signals (MLS) in the deep brain region between 29 and 44 weeks GA. The ventrolateral nuclei (VLN) and subthalamic nuclei (STN) appear to be myelinated before 29 weeks GA. MLS becomes evident in both tracts of the posterior limbs of the internal capsule (PLIC) at approximately 40 weeks GA. This is an important landmark for evaluating neonatal brain development. As the different deep brain region sizes in individual subjects have been corrected through non-rigid registration, the progression of MLS is completely due to the appearance of new myelination without contribution from the overall brain growth.