Fig. 1.

Basic representation of the kinetics of the drug when still encapsulated, where k_PPBX is the rate constant corresponding to the influx of encapsulated PP from the blood, PP is released from the liposomes according to the rate constant k_relX, and k_PPXB represents the rate constant corresponding to the transfer of encapsulated PP to the blood. The transfer of encapsulated PP towards the blood is assumed to be negligible for all tissues studied (see section Calculation of the rate of release). The subsequent kinetics of the released drug is not included in the figure