Table 1.

Kinetic parameters and the corresponding estimated standard error (SE) or estimated standard deviation (SD) for liposomal PP in male C57Bl/6J mice bearing B16F10 melanoma tumors

		SE estimate	SD estimate
CPPB(0)	4.0 × 102 nmol/mL	3 × 101 nmol/mL
kPPB	0.027 h−1	0.004 h−1
CPB(0)a	15 nmol/mL	2 nmol/mL
kPB	0.018 h−1	0.004 h−1
VDPPb	2.2 mL
kPPBT	0.004 mL/g/h	0.001 h−1
krelT	0.03 h−1	0.01 h−1
mTc	0.9 g		0.4 g
kPPBL	0.005 h−1	0.002 h−1
krelL	0.3 h−1	0.1 h−1
mLd	= a x t2 + b x t + c	g
a	−0.00047	0.00005
b	0.030	0.004
c	1.22	0.05
kPPBS	0.0033 h−1	0.0009 h−1
krelS	0.7 h−1	0.1 h−1
mS	0.06 g		0.02 g
kPPBK	0.0007 h−1	0.0001 h−1
krelK	0.10 h−1	0.02 h−1
mK	0.25 g		0.02 g

^a$\frac{{\mathrm{C}}_{\mathrm{PB}}\left(0\right)}{{\mathrm{C}}_{\mathrm{PPB}}\left(0\right)+{\mathrm{C}}_{\mathrm{PB}}\left(0\right)}\times 100\%=3.5\%,$which is similar to the 4.4% non-encapsulated drug in the liposome preparation considering the SE

^bCalculated from Fig. 2 and the dose

^cNo significant trend was observed for the mass of the tumor tissue with time. Quadratic regression of the tumor mass is not significant (p value 0.15)

^dThe mass of the liver varies with time. During the time frame for which the encapsulated PP concentrations are above the lower limit of quantification, the data is significantly not constant and is adequately described by a parabola (p values 0.000)