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. 2019 Sep 10;9:13008. doi: 10.1038/s41598-019-49477-3

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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RPL28 rs4806668G > T polymorphism is associated with survival of mCRC patients treated with FOLFIRI. (a,b) Cox proportional hazards models adjusted for age and co-treatment (Canadian cohort, n = 167) and for age (Italian cohort, n = 250) showed association of rs4806668G > T with progression-free survival (PFS) and overall survival (OS) using a recessive genetic model. Tumor site did not have a statistically significant association with mCRC outcome. (c,d) Univariate Kaplan-Meier survival curves for PFS and OS according to rs4806668G > T genotype in combined cohorts. The percentage survival according to genotypes is shown under the graphs. HR_adj, adjusted hazard ratio; htSNPs, haplotype-tagging single nucleotide polymorphisms; CI, confidence interval.