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. 2019 Sep 10;9:13008. doi: 10.1038/s41598-019-49477-3

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Relationship between RPL28 variants, tissue type and gene expression. (a) RPL28 rs4806668G > T and linked SNPs are associated with an increased gene expression in transverse colon tissues of healthy individuals from the GTEx cohort. (b) RPL28 expression is higher in primary tumor relative to paired normal colorectal tissues (n = 50 pairs) from the TCGA cohort. (c) RPL28 expression is higher in primary colorectal tumors and liver metastases relative to paired normal colorectal tissues (n = 10 pairs) from the GSE49355 dataset. (d) RPL28 expression is higher in primary colorectal tumors and liver metastases relative to paired normal colorectal tissues (n = 18 pairs) from the GSE50760 dataset. A.U., arbitrary units; FPKM, fragments per kilobase million; N, normal tissue; PT, primary tumor tissue; M, liver metastases. *P < 0.05; **P < 0.01; ***P < 0.001.