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. 2019 Sep 10;9:13008. doi: 10.1038/s41598-019-49477-3

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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RPL28 expression level in colorectal tumor tissues is associated with survival and changes in tumor transcriptome. (a) Kaplan-Meier curves for high and low RPL28 expression groups (median separation) of stage IV mCRC individuals from the TCGA cohort (n = 88). The percentage survival according to RPL28 expression group is shown under the graph. (b) Kaplan-Meier curves for high and low RPL28 expression groups (median separation) of stage IV mCRC individuals from the GSE17538 dataset (n = 56). The percentage survival according to RPL28 expression group is shown under the graph. The median and the optimal cut-off values of gene expression were highly similar (Additional file 1: Supplementary Fig. 1). (c) Significantly enriched pathways from differential gene expression in advanced stage IV mCRC cases with high RPL28 expression compared to those with low RPL28 expression from the TCGA cohort. Pathways in blue are enriched with down-regulated genes whereas those in red are enriched with up-regulated genes. Genes belonging to enriched pathways are shown on the right.