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. 2019 Sep 10;9:12932. doi: 10.1038/s41598-019-49275-x

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Rapid cognitive assessment using an eye-tracking system and tasks. (A) The eye tracking system used in the study. The gaze point of the subject was recorded using infrared light sources and cameras located below the monitor. (B) A series of ten task movies and pictures (178 s in total) is displayed on the monitor, and the subject views them. Four representative task movies and pictures are shown. Each task assesses eye movement, deductive reasoning (odd-one-out task), visuospatial function, and working memory (from left to right). Images (gold coin, fishes, and kettle) are obtained from JVC KENWOOD Corporation with permission. (C) An example of a working memory task and representative gaze plots with a duration-based heatmap obtained from a control subject. Gaze plots represent the location and time spent looking at the objects. A cue object (double pentagon) is presented for 10 s (encoding), followed by three distinct objects with the same one as the cue object (right bottom on the monitor, target). The subject is asked to remember and gaze at the target object. Fixation duration within the region of interest (ROI) set on the target object was used as a measure of the cognitive score. Full details of the procedure are described in the Supplemental Information.