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. 2019 Sep 10;9:13014. doi: 10.1038/s41598-019-49484-4

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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The sequential treatment inhibits palbociclib-mediated induction of the PI3K/mTOR pathway. MDA-MB-231 (a) and HCC38 (b) cell lines were incubated for 48 h with 0.5 µM palbociclib and 10 nM paclitaxel, alone or in sequential treatment (Palb → PTX). The expression of the indicated proteins was analyzed by Western blotting. The immunoreactive spots were quantified by densitometric analysis and p-AKT/AKT and p-mTOR/mTOR ratios were calculated; the data are expressed as fold increase versus control (control value = 1). Results are representative of two independent experiments.