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. 2019 Sep 10;9:13024. doi: 10.1038/s41598-019-49536-9

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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CaSr-MOFs induce differentiation of pre-osteoblastic cells to osteoblastic cells, and induce bone mineralization. (A) A brightfield image of CaSr-MOFs with MC3T3 cells. (B) Assay for determining %alive MC3T3 cells in the presence of different MOFs. (C) Alkaline phosphatase generation by MC3T3 in the presence of different MOFs for day 3 and day 7 culture. The no treatment group is the negative control for the corresponding concentration of MOFs. (D) Bone mineralization (shown in green) by MC3T3 in the presence of CaSr-MOF compared to positive (osteogenic medium) and negative (no treatment) controls. (E) Quantification of bone mineralization for treatment with different MOFs.