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. 2019 Sep 10;9:13024. doi: 10.1038/s41598-019-49536-9

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Relative expression levels of mRNA transcripts for osteogenic genes in hMSC monolayers after treatment with MOFs. Results are shown after 14 days of treatment with CaSr-MOFs, CaSr-DMOG-MOFs, or osteogenic medium. (A–F) Expression of ALP, BSP II, RUNX2, OCN, OPN, and COL1. Expression levels are graphed on a log₁₀ scale as fold changes normalized to day 0 baseline values and then to 18S rRNA levels (*p < 0.05, **p < 0.01, ***p < 0.001).