Fig. 5.

Voxel-level spatial covariation in Social and CS mediation (path ab) effects. Scatter plots display unthresholded single-voxel beta weights for CS (y-axis) and Social (x-axis) mediation effects (path ab). Each dot represents a voxel. Different colors are assigned to eight octants that reflect positive mediation for CS but not Social effects (Octant 1), positive mediation effects for both (Octant 2), positive mediation of Social, but not CS effects (Octant 3), and so on. Radial grids display distance from the origin (0,0) in 0.02 unit steps. These maps are descriptive, unthresholded illustrations of mediation beta weights. Units are arbitrary. a Voxel-level similarity in the frontoparietal network, showing the highest sum of squared distances (SSD, displayed in bar plots) from the origin in Octants 2 and 3, reflecting shared (CS and Social) positive and uniquely positive mediation of Social effects, respectively. Voxels in Octants 1–3 (green, blue, and purple, respectively) within the frontoparietal network (light gray area) are displayed on a lateral brain surface plot (far right). b Voxel-level similarity in the limbic network, showing highest SSD in Octants 1 and 8 (see bar plot), reflecting selective mediation of CS effects and suppression of Social effects. Suppression effects are in the opposite direction from, and thus “work against”, the overall effects of cues on pain ratings. Voxels in Octants 1–3 (green, blue, and purple, respectively) in the limbic network (light gray area) are plotted on a medial brain surface (far right). See Supplementary Fig. 6 for the results in all seven large-scale networks. Source data are provided as a Source Data file