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. 2019 Sep 4;10:2050. doi: 10.3389/fimmu.2019.02050

Figure 1.

Figure 1

Loss of Bach2 in T cells causes humoral autoimmunity. (A,B) Body weight (A) and survival rate (B) of wild-type (WT), Bach2ΔCD4, or Bach2ΔCD19 mice at 5 months of age. (C) Titer of anti-dsDNA antibodies and anti-nuclear antibodies (ANA) in the sera of WT, Bach2ΔCD4, or Bach2ΔCD19 mice at 2–3 months of age. (D) Titers of immunoglobulins in sera of WT and Bach2ΔCD4 mice at 2–3 months of age. (E) Titers of anti-dsDNA and ANA IgG1 in the sera of WT and Bach2ΔCD4 mice at 2–3 months of age. (F) Immunochemistry of IgG deposit in renal glomeruli. (G) Representative images (left) of spleen and lymph nodes of WT and Bach2ΔCD4 mice at 5 months of age. The weight of spleens from indicated mice is shown at the right. Each symbol represents one mouse; small horizontal lines indicate the mean; ns, not significant; *P < 0.05 and **P < 0.01 (two-tailed t-test).