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. 2019 Sep 4;10:2050. doi: 10.3389/fimmu.2019.02050

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Copyright © 2019 Zhang, Hu, Zhang, Yang, Peng, Zhang and Huang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The Bcl6 heterozygosity significantly reduced autoantibodies and pathology. (A,B) The frequencies of Tfh and GC B cells in the MLNs and spleens from Bach2^Δ^CD4 and Bcl6^fl/+Bach2^Δ^CD4 mice. (C) Body weight and survival of Bach2^Δ^CD4 and Bcl6^fl/+Bach2^Δ^CD4 mice. (D) Titers of anti-dsDNA and anti-ANA antibodies in sera from Bach2^Δ^CD4 and Bcl6^fl/+Bach2^Δ^CD4 mice. All mice were analyzed at 5–6 months of age. Each symbol represents one mouse; small horizontal lines indicate the mean. ns, not significant; ^*P < 0.05 and ^**P < 0.01 (two-tailed t-test).