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. 2019 Sep 4;6:78. doi: 10.3389/fmolb.2019.00078

Figure 1.

Figure 1

Cell cycle- and DNA damage-activated kinases lead to formation of a ternary complex formed by Fun30SMARCAD1, Dpb11TOPBP1, and the 9-1-1 complex (adapted from Bantele et al., 2017; Bantele, 2018). Upon CDK-dependent phosphorylation of Fun30 S20/S28 or SMARCAD1 T71, respectively, Fun30 and SMARCAD1 associate with BRCT1+2 of Dpb11 or BRCT0/1/2 of TOPBP1. In yeast, binding to the 9-1-1 complex (in a DNA damage-induced manner) contributes to localization of Fun30-Dpb11 to sites of DNA end resection, where it stimulates long-range resection (Chen et al., 2012; Costelloe et al., 2012; Eapen et al., 2012; Bantele et al., 2017).