Figure 6.

GYY4137 exacerbates plasma extravasation in arthritic tibiotarsal joints of TRPA1 KO mice. (A) Edema formation characterized by extravasation of micellar fluorescent IR-676 dye in tibiotarsal joints of GYY4137-treated (50 mg kg⁻¹day⁻¹i.p.) and vehicle-treated TRPA1 WT and KO mice undergoing K/BxN arthritis on days 2 and 6 expressed as (photons s⁻¹)(μW cm⁻²)⁻¹. (B) Representative fluorescence images showing plasma protein extravasation characterized by extravasation of micellar IR-676 dye in tibiotarsal joints of GYY4137- and vehicle-treated TRPA1 WT and KO mice undergoing K/BxN arthritis. Data are shown as mean ± SEM of n = 9–10 mice per group. *p < 0.05 vs. GYY4137-treated TRPA1 WT mice. ^# p < 0.05 vs. TRPA1 KO animals treated with vehicle of GYY4137.