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. 2019 Sep 10;10(9):653. doi: 10.1038/s41419-019-1877-6

Fig. 4. Lactate and pyruvate promote stress resistance and induce cellular stress response.

Fig. 4

a Survival curves of wild-type nematodes supplemented with lactate or pyruvate treated with 300 μM juglone (p < 0.0001) b, c Lifespan curves of wild-type animals treated with 100 mM (b) or 10 mM (c) lactate or pyruvate. d–h Representative GFP fluorescence images and quantitative measurements of GFP fluorescence intensities in C.elegans expressing transcriptional reporters, as indicated in the left margin, treated with 10 mM lactate or pyruvate. i Immunoblot analysis of HIF1α and HSP4/GRP78 protein expression in wild-type nematode. Tubulin is used as a loading control. (N = 3, *p < 0.05, **p < 0.01, ***p < 0.001, and ****p < 0.0001)