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. 2019 Sep 10;9:13000. doi: 10.1038/s41598-019-49353-0

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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AD-related thinning and thickening of retinal layers. The top row shows data for the total retina; subsequent rows show data for each of its layers. (a) The first column shows the color-coded thickness difference between patients and controls for each scanned retinal point. (b) The second column displays the histogram and the cumulative distribution function for all those differences, together with its mean and SD. (c) The third column shows the regions where layers are thinner (black) or thicker (white) in patients, irrespective of the size of the difference. (d) The right-most column shows thinner (black) and thicker (white) regions where the difference >1 SD; regions with a smaller difference appear in gray. The two values collected under each image of the two right-most columns refer to the percentages of thinned (t) and thickened (T) areas in the image above.