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. 2019 Sep 10;9:13000. doi: 10.1038/s41598-019-49353-0

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Parameters for spatial normalization: center of the fovea c_m, center of the papilla c_p, length s and angle θ of maculopapillar axis. All OCTs were moved, rotated and scaled so that their macular and papillar centers overlapped. Data on macula and papilla were acquired independently in two OCT sessions, so their coordinate systems could not be directly related to each other. Thus, the two datasets had to be co-registered based on shared retinal regions before maculopapilar axis length and angle could be computed.