Table 2.
Spatial coincidence of thinned and thickened regions across retinal layers in AD patients.
| NFL | GCL | IPL | INL | OPL | ONL | IS/OS | OSL | OPR | RPE | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Thickness differences of any size | ||||||||||||||||||||
| NFL | 1 | 0.25 | ** | 0.13 | ** | 0.09 | * | 0.22 | ** | 0.09 | ** | 0.39 | — | 0.01 | — | 0.06 | ** | 0.38 | — | |
| GCL | 0.46 | *** | 1 | 0.11 | ** | 0.09 | * | 0.17 | ** | 0.18 | ** | 0.39 | — | 0.01 | — | 0.09 | * | 0.33 | * | |
| IPL | 0.54 | *** | 0.42 | *** | 1 | 0.04 | * | 0.12 | ** | 0.31 | * | 0.19 | ** | 0.01 | — | 0.09 | ** | 0.21 | * | |
| INL | 0.67 | *** | 0.57 | *** | 0.72 | *** | 1 | 0.00 | ** | 0.10 | * | 0.08 | * | 0.02 | — | 0.02 | ** | 0.06 | * | |
| OPL | 0.58 | *** | 0.46 | *** | 0.58 | *** | 0.68 | *** | 1 | 0.03 | ** | 0.21 | ** | 0.00 | — | 0.07 | ** | 0.26 | * | |
| ONL | 0.46 | *** | 0.43 | *** | 0.68 | *** | 0.70 | *** | 0.47 | *** | 1 | 0.14 | ** | 0.01 | — | 0.05 | ** | 0.30 | * | |
| IS/OS | 0.58 | *** | 0.49 | *** | 0.49 | *** | 0.56 | *** | 0.48 | *** | 0.39 | *** | 1 | 0.00 | — | 0.08 | ** | 0.38 | — | |
| OSL | 0.68 | *** | 0.56 | *** | 0.76 | *** | 0.93 | *** | 0.73 | *** | 0.71 | *** | 0.56 | *** | 1 | 0.01 | — | 0.00 | — | |
| OPR | 0.62 | *** | 0.53 | *** | 0.71 | *** | 0.85 | *** | 0.68 | *** | 0.64 | *** | 0.52 | *** | 0.90 | *** | 1 | 0.04 | ** | |
| RPE | 0.33 | — | 0.18 | ** | 0.24 | * | 0.27 | — | 0.27 | * | 0.28 | * | 0.23 | ** | 0.27 | 0.21 | * | 1 | ||
| Thickness differences >1 SD | ||||||||||||||||||||
| NFL | GCL | IPL | INL | OPL | ONL | IS/OS | OSL | OPR | RPE | |||||||||||
| NFL | 1 | 0.02 | ** | 0.00 | * | 0.00 | — | 0.11 | * | 0.00 | ** | 0.07 | ** | na | 0.01 | — | 0.16 | * | ||
| GCL | 0.28 | ** | 1 | 0.00 | * | 0.02 | — | 0.09 | * | 0.06 | ** | 0.09 | ** | na | 0.01 | — | 0.07 | ** | ||
| IPL | 0.28 | ** | 0.23 | ** | 1 | 0.00 | — | 0.03 | * | 0.06 | * | 0.01 | * | na | 0.00 | — | 0.04 | * | ||
| INL | 0.35 | * | 0.35 | — | 0.43 | *** | 1 | 0.00 | — | 0.00 | — | 0.03 | — | na | 0.00 | — | 0.00 | — | ||
| OPL | 0.17 | ** | 0.20 | ** | 0.24 | ** | 0.22 | ** | 1 | 0.00 | ** | 0.05 | ** | na | 0.00 | — | 0.08 | * | ||
| ONL | 0.35 | * | 0.23 | ** | 0.37 | * | 0.43 | *** | 0.12 | ** | 1 | 0.01 | ** | na | 0.00 | — | 0.14 | * | ||
| IS/OS | 0.16 | ** | 0.30 | * | 0.22 | ** | 0.25 | * | 0.16 | ** | 0.12 | ** | 1 | na | 0.00 | — | 0.08 | * | ||
| OSL | 0.40 | *** | 0.29 | — | 0.42 | *** | 0.62 | *** | 0.31 | * | 0.51 | *** | 0.23 | — | 1 | na | na | |||
| OPR | 0.24 | ** | 0.22 | ** | 0.29 | ** | 0.35 | * | 0.22 | ** | 0.31 | ** | 0.17 | ** | 0.40 | *** | 1 | 0.00 | — | |
| RPE | 0.13 | * | 0.01 | ** | 0.08 | * | 0.08 | * | 0.07 | ** | 0.09 | * | 0.04 | ** | 0.08 | * | 0.03 | ** | 1 | |
Jaccard coefficients for spatial coincidence of thinned regions of each pair of layers are shown below the main diagonals of the two correlation matrices; coefficients for thickened regions are shown above. The matrix on the top has been obtained when the classification of regions as thinned or thickened was based on thickness differences of any size between AD and control groups; and the matrix at the bottom when differences >1 SD were required. Results of statistical significance testing are indicated as follows: —, statistically non-significant; *p < 0.05; **p < 0.01; ***p < 0.001, where these p values represent the probability of family-wise type I error in two-tailed tests for the set of 45 Jaccard values obtained for thinned/thickened regions.