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. 2019 Sep 10;9:12940. doi: 10.1038/s41598-019-49383-8

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Effect of Kava-205Me treatment on cytokine secretion from P. gingivalis-stimulated BMM. The BioPlex Pro Mouse Cytokine 23-plex Assay was utilized to determine the cytokine levels in BMM culture supernatants stimulated with P. gingivalis for 4 hrs. The data presented are means of 3 replicates. Eight of 23 cytokines showed significant reductions after Kava-205Me treatment (50 μg/ml). Unpaired t-test was performed for P. gingivalis vs P. gingivalis + Kava-205Me (*p < 0.05; **p < 0.01; ***p < 0.001).