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. 2019 Sep 10;9:12940. doi: 10.1038/s41598-019-49383-8

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Effect of Kava-205Me on calvarial healing. Injection of Kava-205Me (1 mg) significantly decreased P. gingivalis-induced calvarial destruction. After 4 days, calvarial wounds in treated mice had largely closed while wounds in untreated mice still exhibited large lesions (A,B). At the histological level, a decreased number of inflammatory cells within soft tissue was observed in the Kava-205Me group, and fewer for TRAP positive cells were observed (C). Quantitative evaluation of histological changes following Kava-205Me treatment (inflammation score; osteoclast index, osteoclast-covered surface) (D). *p < 0.05.