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. 2019 Sep 10;10(9):661. doi: 10.1038/s41419-019-1874-9

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a Forest plot illustrating the Hazard ratios (HRs) of fixed-effect meta-analysis summary result for each of the 16 chemotherapy-responsive genes. The HR shown for each gene is leveraged from univariate and multivariate Cox-PH analysis across 21 ovarian cancer cohorts. Colored rectangles on the left indicate the logFC of gene expression comparing chemo-sensitive to chemo-resistant tumors. b Kaplan–Meier curves of OS for patients divided by the IndividCRS in the Patch and TCGA datasets. Significance was determined using the log-rank test. c Distribution of the IndividCRS and expression heatmap of 16 chemotherapy-responsive genes in the Patch and TCGA datasets. HR, hazard ratio; OS, overall survival; IndividCRS, individual chemotherapeutic response scores; TCGA, The Cancer Genome Atlas Network; CR: Complete response; PR: partial response; PD: progression disease; SD: stable disease