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. Author manuscript; available in PMC: 2019 Sep 11.
Published in final edited form as: J Pathol. 2018 Apr 20;245(2):209–221. doi: 10.1002/path.5080

Figure 1.

Figure 1.

CGKRK peptide has high binding affinity for angiogenic blood vessels in orthotopic GBM models. (A) Treatment scheme of mice bearing NSCG-GBMs or NFpp10-GBMs with peptide-tagged micelles. (B) Immunohistochemical analysis of NSCG-GBM after micelle injection. FAM-labelled micelles were injected without peptide (control, Ctrl) or tagged with RGR-FAM, CGKRK-FAM or NGR-FAM peptides (green), and peptide-covered (yellow) CD31+ (red) tumour vessels were quantified; n=2, 200–400 blood vessels/mouse, ***p < 0.0001. (C) Quantitative analysis of peptide-loaded micelles in relation to blood vessels in NFpp10-GBM as in (B); n=2 mice/group, 200–400 blood vessels/mouse. *p =0.022, ***p < 0.0001, ANOVA. Arrows point to some blood vessels with bound peptides. (D) Representative images of FAM-peptide homing to normal brain (control). Scale bars: 50 μm. i.v., intravenous.