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. 2019 Sep 6;14:7263–7279. doi: 10.2147/IJN.S212978

Figure 2.

Figure 2

Synthetic route of RGDV-gemcitabine (4)a.

Notes: aReagents: i) DCC, HOBt, NMM and THF; ii) CH3OH and aqueous NaOH (4 M); iii) CH3OH and Pd/C; iv) DCC, HOBt and DMF; v) Hydrochloride in ethyl acetate (4 M).

Abbreviations: DCC, dicyclohexylcarbodiimide; HOBt, N-hydroxybenzotriazole; NMM, N-methylmorpholine; THF, tetrahydrofuran; DMF, N,N-dimethylformamide; RGDV-gemcitabine, 4-(Arg-Gly-Asp-Val-amino)-1-[3,3-difluoro-4-hydroxy-5-(hydroxylmethyl)oxo-lan-2-yl]pyrimidin-2-one.