Figure 3.

Mapping of water accessibility changes. A, the ratio (R) of hydroxyl reactivity rates as described in Table 1 for each residue or peptide shows decreased (red shades), increased (blue shades), or unchanged (gray) water accessibility in response to zinc binding. B, modified residues (sticks) and peptides (ribbons) in the crystal structure of Zn/Cd-ZIPB (PDB code 5TSA) (5) are colored according to the direction of water accessibility change as described in A. Peptides not detected are colored light orange. Bound Zn, Cd, and water molecules are shown as slate gray, orange, and cyan spheres, respectively.