Table 1.

Thermodynamic parameters for nucleation and fibril growth in fibril formation of apoA-I 1–83/G26R and deletion variants

The data were from at least three independent experiments.

	ΔH*a	ΔS*a	ΔG*b
	kJ/mol	J/mol K	kJ/mol
ApoA-I 1–83/G26R
Nucleation (k1)	126 ± 20	55 ± 14	109
Fibril growth (k2)	65 ± 6	−122 ± 33	103
Δ32–40
Nucleation (k1)	77 ± 12	−122 ± 64	115
Fibril growth (k2)	87 ± 22	−47 ± 14	102
Δ50–58
Nucleation (k1)	22 ± 14	−281 ± 160	110
Fibril growth (k2)	98 ± 6	−20 ± 2	104
Δ68–76
Nucleation (k1)	137 ± 16	70 ± 14	115
Fibril growth (k2)	47 ± 10	−170 ± 45	100

^a ΔH* and ΔS* were obtained from the slope and y-intercept of the linear plot, respectively, according to Equation 3.

^b ΔG* was calculated from ΔH* and ΔS* according to ΔG* = ΔH* − TΔS* at 37 °C.