Figure 4.

Effects of the 5HT_2c agonist WAY163909 administration on c-Fos immunoreactive cells in adult PWS^ICdel mice. c-fos reactivity was assessed in two brain regions, the OFC and the nucleus accumbens (A). 1 mg/kg WAY163909 significantly increased the number of c-Fos positive cells in the OFC in WT, but not PWS^ICdel mice (B). WAY163909 did not affect the number of c-Fos positive cells in the nucleus accumbens, for either WT pr PWS^ICdel mice (C). Data shows mean ± SE. # denotes P < 0.05 for comparison of vehicle to WAY163909 for each group.