Table 1.
Task shaping and comparison of gender during training and at with 50% stopping ability
| Number of | Shaping and training | Performance at 50% correct stopping | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| subjects | Going | Stopping | |||||||||
| Start | At BL |
Sessions to BL | Sessions to stable BL performance | Duration of go stimulus (ms) | Correct responses (%) | Reaction time (ms) | Time to withhold responding (ms) | Correct responses (%) | SSRT (ms) |
||
| WT | Male | 4 | 4 | 44.25 ± 1.65 | 13.75 ± 5.17 | 1475.00 ± 137.69 | 78.31 ± 3.23 | 877.78 ± 49.27 | 612.50 ± 42.70 | 52.76 ± 3.24 | 450.15 ± 63.17 |
| Female | 11 | 9 | 37.22 ± 2.38 | 13.78 ± 3.22 | 1100.00 ± 27.39 | 84.55 ± 5.59 | 718.58 ± 52.19 | 533.33 ± 37.91 | 46.96 ± 1.22 | 349.50 ± 56.60 | |
| All WT | 15 | 13 | 39.38 ± 2.62 | 13.77 ± 2.62 | 1215.38 ± 65.87 | 82.63 ± 3.99 | 798.33 ± 51.35 | 557.69 ± 31.44 | 48.74 ± 1.45 | 380.47 ± 44.33 | |
| PWSICdel | Male | 10 | 9 | 43.56 ± 0.80 | 8.11 ± 1.97 | 1134.72 ± 91.52 | 85.58 ± 3.13 | 744.50 ± 54.24 | 583.33 ± 47.14 | 50.22 ± 1.50 | 499.95 ± 39.86 |
| Female | 6 | 5 | 41.60 ± 0.80 | 11.80 ± 3.26 | 1120.00 ± 60.42 | 90.75 ± 2.73 | 751.65 ± 36.64 | 670.00 ± 46.37 | 46.31 ± 4.56 | 531.74 ± 64.98 | |
| All PWSICdel | 16 | 14 | 42.86 ± 0.65 | 9.43 ± 1.72 | 1129.46 ± 60.98 | 87.43 ± 2.27 | 747.05 ± 36.23 | 614.29 ± 35.33 | 48.82 ± 1.86 | 511.30 ± 33.32 | |
| WT: GENDER comparison | P = 0.098 | P = 0.421 | P = 0.069 | P = 0.354 | P = 0.064 | P = 0.212 | P = 0.171 | P = 0.270 | |||
| PWSICdel GENDER comparison | P = 0.156 | P = 0.365 | P = 0.895 | P = 0.238 | P = 0.915 | P = 0.217 | P = 0.453 | P = 0.689 | |||
Notes: Sessions to BL reflect the number of sessions taken to progress through the first stages of training (See Supplementary Material, Table S1), and sessions for stable BL performance the number of sessions for consistent intra-session performance in the full SSRTT with stop-signal presentation coincident with the start of the go response (i.e. a 0% stop-signal delay). Other measures are from when individualized performance was assessed over the range of stop-signal positions used (10%, 20%, 30%, 40%, 50%, 60%, 70%, 80% and 90% of the go response) and 50% stopping was calculated. Separate unpaired two-tailed t-tests were used for the gender comparisons for each genotype. Data shows mean ± SE. SSRT: stop-signal reaction time (see main text for derivation).